The combat system in Devil May Cry 5 is widely praised for its depth, flexibility, and adaptability, allowing players to tailor their fighting style to their preferences. Reviewers highlight the game's freedom and challenge, with three distinct characters—Nero, V, and Dante—each offering unique combat styles and abilities. Nero's Devil Breakers add strategic depth, while V provides a simpler, more relaxed combat experience. Dante's vast arsenal of weapons and stances, which can be swapped mid-combo, contributes to a deep and rewarding combat experience. The system's complexity and responsiveness, particularly the parry system, reward timing precision and enhance replayability. The variety of weapons and special moves, along with the high degree of customization, make combat engaging and rewarding. Points of agreement across assessments include the combat system's depth, customization options, and the rewarding nature of mastering different characters and styles.

Devil May Cry 5 excels in its art style, leveraging the Resident Evil engine to deliver stunning, photorealistic visuals that uphold the series' tradition of cutting-edge graphics. The game's environments, while somewhat repetitive, are visually impressive and well-designed, particularly highlighted by advanced character models and detailed animations. Assessments agree on the game's feast for the senses, especially during action sequences, with impressive particle effects and imaginative weapon designs. The detailed graphics and animations significantly enhance the spectacle of combat, making it a standout feature of the game.

The characters in Devil May Cry 5 are well-developed, with returning characters like Dante offering familiar fan-pleasing moments and new characters like V and Nico adding depth and interest. Each character has a unique combat style and personality that contributes to the overall narrative and player experience.

The gameplay mechanics of the game are widely praised for their intuitive design and depth. Assessment 1 highlights the well-designed character switching, difficulty levels, and a challenging progression system that promotes multiple playthroughs. Assessment 2 emphasizes the intricate and rewarding nature of the mechanics, particularly the introduction of new elements like V's demon summoning, which encourages experimentation and mastery of different combat styles. Both assessments agree on the quality and depth of the mechanics, though Assessment 2 places a specific emphasis on the innovative aspects that enhance gameplay.

Narrative elements are deeply integrated into the gameplay, with story progression and character development influencing gameplay decisions and outcomes.

The game demonstrates high technical quality, running smoothly on the Resident Evil engine with minimal load times and a stable frame rate. Assessments agree on the game's well-optimized graphics and high-quality visuals, which are maintained without compromising performance. The inclusion of a photo mode is praised for allowing players to appreciate the detailed character models and effects. However, there are points of contention regarding the repetitiveness of some environments and minor issues with camera control. While the overall performance is stable and impressive, certain areas could benefit from further refinement to enhance the player experience.

The sound design of the game is largely praised across assessments for its effective use of audio techniques and its contribution to the game's atmosphere. Assessments 1 and 2 highlight the effective use of sidechaining to prioritize important audio elements, such as character dialogue and creature effects, and commend the crisp and immersive sound effects. Assessment 2 specifically notes the exceptional soundtrack that enhances the gameplay experience. Assessment 3 adds that the soundtrack is dynamic, adapting to the player's performance, and praises the quality of the sound design, including voice acting. However, Assessment 1 points out a notable disagreement regarding the voice acting for the main antagonist, which is described as poor. Overall, while there is strong agreement on the quality of the sound design, there is a minor point of contention regarding the voice acting for the main antagonist.

The story of Nero hunting demons and teaming up with Nico to confront a new demonic presence is a central focus of the game, introducing new characters and lore. While Assessment 1 notes that the narrative feels rushed and leaves some elements underdeveloped, Assessment 2 highlights the complexity and non-linearity of the story, which may confuse new players. However, it also points out that the Cameo system adds depth. In contrast, Assessment 3 praises the narrative for its rich character development, emotional moments, and strong ties to previous installments, providing both closure and new revelations. Points of agreement include the introduction of new lore and the complexity of the narrative, while disagreements center on the perceived rushed nature of the story and its clarity for new players.

The game has a strong narrative focus, with a well-controlled storyline, several well-calculated twists, and a coherent plot that is enjoyable to discover as players progress. The game also features a rich cast of characters, each with distinct combat styles and interesting personalities, making the campaign engaging for fans of the series.

Devil May Cry 5's graphics have seen significant improvements, particularly in level of detail, animations, and facial textures. The game utilizes a more realistic yet over-the-top graphical style, leveraging the RE Engine. However, some inconsistent textures and performance issues during cutscenes detract from the overall experience.